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Translating 3D printed pharmaceuticals: From hype to real-world clinical applications

Seoane-Viaño, I; Trenfield, SJ; Basit, AW; Goyanes, Á; (2021) Translating 3D printed pharmaceuticals: From hype to real-world clinical applications. Advanced Drug Delivery Reviews , 174 pp. 553-575. 10.1016/j.addr.2021.05.003.

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Abstract

Three-dimensional (3D) printing is a revolutionary technology that is disrupting pharmaceutical development by enabling the production of personalised printlets (3D printed drug products) on demand. By creating small batches of dose flexible medicines, this versatile technology offers significant advantages for clinical practice and drug development, namely the ability to personalise medicines to individual patient needs, as well as expedite drug development timelines within preclinical studies through to first-in-human (FIH) and Phase I/II clinical trials. Despite the widely demonstrated benefits of 3D printing pharmaceuticals, the clinical potential of the technology is yet to be realised. In this timely review, we provide an overview of the latest cutting-edge investigations in 3D printing pharmaceuticals in the pre-clinical and clinical arena and offer a forward-looking approach towards strategies to further aid the translation of 3D printing into the clinic.

Type: Article
Title: Translating 3D printed pharmaceuticals: From hype to real-world clinical applications
Location: Netherlands
DOI: 10.1016/j.addr.2021.05.003
Publisher version: https://doi.org/10.1016/j.addr.2021.05.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Additive manufacturing, 3D printing formulations, Personalized drug products and translational pharmaceutics, Printed oral drug delivery systems, Mass customization and personalization, Early phase therapeutics development and computational modeling, Artificial intelligence and industry 4.0, Biomedical engineering and medical devices
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10128710
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