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Optical biosensors - Illuminating the path to personalized drug dosing

Ong, JJ; Pollard, TD; Goyanes, A; Gaisford, S; Elbadawi, M; Basit, AW; (2021) Optical biosensors - Illuminating the path to personalized drug dosing. Biosensors and Bioelectronics , 188 , Article 113331. 10.1016/j.bios.2021.113331. Green open access

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Abstract

Optical biosensors are low-cost, sensitive and portable devices that are poised to revolutionize the medical industry. Healthcare monitoring has already been transformed by such devices, with notable recent applications including heart rate monitoring in smartwatches and COVID-19 lateral flow diagnostic test kits. The commercial success and impact of existing optical sensors has galvanized research in expanding its application in numerous disciplines. Drug detection and monitoring seeks to benefit from the fast-approaching wave of optical biosensors, with diverse applications ranging from illicit drug testing, clinical trials, monitoring in advanced drug delivery systems and personalized drug dosing. The latter has the potential to significantly improve patients' lives by minimizing toxicity and maximizing efficacy. To achieve this, the patient's serum drug levels must be frequently measured. Yet, the current method of obtaining such information, namely therapeutic drug monitoring (TDM), is not routinely practiced as it is invasive, expensive, time-consuming and skilled labor-intensive. Certainly, optical sensors possess the capabilities to challenge this convention. This review explores the current state of optical biosensors in personalized dosing with special emphasis on TDM, and provides an appraisal on recent strategies. The strengths and challenges of optical biosensors are critically evaluated, before concluding with perspectives on the future direction of these sensors.

Type: Article
Title: Optical biosensors - Illuminating the path to personalized drug dosing
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bios.2021.113331
Publisher version: https://doi.org/10.1016/j.bios.2021.113331
Language: English
Additional information: Copyright © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Digital healthcare, Industry 4.0, Personalized biopharmaceuticals and drug products, Precision medicine, Therapeutic drug monitoring, Translational pharmaceutical sciences
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10128706
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