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Visual intracortical and transthalamic pathways carry distinct information to cortical areas.

Blot, A; Roth, MM; Gasler, I; Javadzadeh, M; Imhof, F; Hofer, SB; (2021) Visual intracortical and transthalamic pathways carry distinct information to cortical areas. Neuron 10.1016/j.neuron.2021.04.017. (In press). Green open access

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Abstract

Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual system of rodents. The fine-scale organization and function of these cortico-thalamo-cortical pathways remains unclear. We find that responses of mouse LP neurons projecting to higher visual areas likely derive from feedforward input from primary visual cortex (V1) combined with information from many cortical and subcortical areas, including superior colliculus. Signals from LP projections to different higher visual areas are tuned to specific features of visual stimuli and their locomotor context, distinct from the signals carried by direct intracortical projections from V1. Thus, visual transthalamic pathways are functionally specific to their cortical target, different from feedforward cortical pathways, and combine information from multiple brain regions, linking sensory signals with behavioral context.

Type: Article
Title: Visual intracortical and transthalamic pathways carry distinct information to cortical areas.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2021.04.017
Publisher version: https://doi.org/10.1016/j.neuron.2021.04.017
Language: English
Additional information: Copyright 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: higher visual areas, pulvinar, thalamocortical interactions, thalamus, vision, visual cortex, visual processing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/10128661
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