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Intraoperative hyperspectral label-free imaging: from system design to first-in-patient translation.

Michael, E; Nabavi, E; Shapey, J; Xie, Y; Liebmann, F; Spirig, JM; Hoch, A; ... Vercauteren, T; + view all (2021) Intraoperative hyperspectral label-free imaging: from system design to first-in-patient translation. Journal of Physics D: Applied Physics , 54 (29) , Article 294003. 10.1088/1361-6463/abfbf6. Green open access

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Abstract

Despite advances in intraoperative surgical imaging, reliable discrimination of critical tissue during surgery remains challenging. As a result, decisions with potentially life-changing consequences for patients are still based on the surgeon's subjective visual assessment. Hyperspectral imaging (HSI) provides a promising solution for objective intraoperative tissue characterisation, with the advantages of being non-contact, non-ionising and non-invasive. However, while its potential to aid surgical decision-making has been investigated for a range of applications, to date no real-time intraoperative HSI (iHSI) system has been presented that follows critical design considerations to ensure a satisfactory integration into the surgical workflow. By establishing functional and technical requirements of an intraoperative system for surgery, we present an iHSI system design that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two systems exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were designed and investigated by performing assessments against established design criteria and ex vivo tissue experiments. Finally, we report the use of our real-time iHSI system in a clinical feasibility case study as part of a spinal fusion surgery. Our results demonstrate seamless integration into existing surgical workflows.

Type: Article
Title: Intraoperative hyperspectral label-free imaging: from system design to first-in-patient translation.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1361-6463/abfbf6
Publisher version: https://doi.org/10.1088/1361-6463/abfbf6
Language: English
Additional information: Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Keywords: computer assisted interventions, exoscope, first-in-patient, hyperspectral imaging, medical device, translational research
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10128594
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