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Do statins reduce mortality in older people? Findings from a longitudinal study using primary care records

Gitsels, LA; Bakbergenuly, I; Steel, N; Kulinskaya, E; (2021) Do statins reduce mortality in older people? Findings from a longitudinal study using primary care records. Family Medicine and Community Health , 9 (2) , Article e000780. 10.1136/fmch-2020-000780. Green open access

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Abstract

OBJECTIVE: Assess whether statins reduce mortality in the general population aged 60 years and above. DESIGN: Retrospective cohort study. SETTING: Primary care practices contributing to The Health Improvement Network database, England and Wales, 1990–2017. PARTICIPANTS: Cohort who turned age 60 between 1990 and 2000 with no previous cardiovascular disease or statin prescription and followed up until 2017. RESULTS: Current statin prescription was associated with a significant reduction in all-cause mortality from age 65 years onward, with greater reductions seen at older ages. The adjusted HRs of mortality associated with statin prescription at ages 65, 70, 75, 80 and 85 years were 0.76 (95% CI 0.71 to 0.81), 0.71 (95% CI 0.68 to 0.75), 0.68 (95% CI 0.65 to 0.72), 0.63 (95% CI 0.53 to 0.73) and 0.54 (95% CI 0.33 to 0.92), respectively. The adjusted HRs did not vary by sex or cardiac risk. CONCLUSIONS: Using regularly updated clinical information on sequential treatment decisions in older people, mortality predictions were updated every 6 months until age 85 years in a combined primary and secondary prevention population. The consistent mortality reduction of statins from age 65 years onward supports their use where clinically indicated at age 75 and older, where there has been particular uncertainty of the benefits.

Type: Article
Title: Do statins reduce mortality in older people? Findings from a longitudinal study using primary care records
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/fmch-2020-000780
Publisher version: http://dx.doi.org/10.1136/fmch-2020-000780
Language: English
Additional information: © Author(s) (or their employer[s]) 2021. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10128463
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