UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?

Bhat, A; Parr, T; Ramstead, M; Friston, K; (2021) Immunoceptive inference: why are psychiatric disorders and immune responses intertwined? Biology & Philosophy , 36 (3) , Article 27. 10.1007/s10539-021-09801-6. Green open access

[thumbnail of Bhat_Immunoceptive inference- why are psychiatric disorders and immune responses intertwined_VoR.pdf]
Preview
Text
Bhat_Immunoceptive inference- why are psychiatric disorders and immune responses intertwined_VoR.pdf - Published version

Download (1MB) | Preview

Abstract

There is a steadily growing literature on the role of the immune system in psychiatric disorders. So far, these advances have largely taken the form of correlations between specific aspects of inflammation (e.g. blood plasma levels of inflammatory markers, genetic mutations in immune pathways, viral or bacterial infection) with the development of neuropsychiatric conditions such as autism, bipolar disorder, schizophrenia and depression. A fundamental question remains open: why are psychiatric disorders and immune responses intertwined? To address this would require a step back from a historical mind-body dualism that has created such a dichotomy. We propose three contributions of active inference when addressing this question: translation, unification, and simulation. To illustrate these contributions, we consider the following questions. Is there an immunological analogue of sensory attenuation? Is there a common generative model that the brain and immune system jointly optimise? Can the immune response and psychiatric illness both be explained in terms of self-organising systems responding to threatening stimuli in their external environment, whether those stimuli happen to be pathogens, predators, or people? Does false inference at an immunological level alter the message passing at a psychological level (or vice versa) through a principled exchange between the two systems?

Type: Article
Title: Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10539-021-09801-6
Publisher version: https://doi.org/10.1007/s10539-021-09801-6
Language: English
Additional information: © 2021 Springer Nature Switzerland AG. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Active inference, Autoimmunity, Diaschisis, Immunoceptive inference, Immunology, Pregnancy, Psychiatry, Sensory attenuation, Threat avoidance
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10128456
Downloads since deposit
12Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item