UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients

Martin, DS; McNeil, M; Brew-Graves, C; Filipe, H; O’Driscoll, R; Stevens, JL; Burnish, R; ... Grocott, MPW; + view all (2021) A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients. Journal of the Intensive Care Society 10.1177/17511437211010031. Green open access

[thumbnail of Williams_TOXYC Manuscript_Revised (1).pdf]
Preview
Text
Williams_TOXYC Manuscript_Revised (1).pdf - Accepted version

Download (483kB) | Preview

Abstract

Background: Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO ) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients. Methods: We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO 88–92%) or usual care (control – SpO ≥96%). The primary outcome was feasibility; factors related to safety and clinical outcomes were also assessed. Results: A total of 34 patients were recruited into the study until it was stopped due to time constraints. A number of key barriers to success were identified during the course of the study. The conservative oxygenation intervention was feasible and appeared to be safe in this small patient cohort and it achieved wide separation of the median time-weighted average (IQR) SpO at 91% (90–92%) in conservative oxygenation group versus 97% (96–97%) in control group. Conclusion: Whilst conservative oxygenation was a feasible and safe intervention which achieved clear group separation in oxygenation levels, the model used in this trial will require alterations to improve future participant recruitment rates in the UK. 2 2 2 2

Type: Article
Title: A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/17511437211010031
Publisher version: https://doi.org/10.1177%2F17511437211010031
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Oxygen, hypoxaemia, intensive care, critical illness, mechanical ventilation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10128366
Downloads since deposit
11Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item