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Study on the cytocompatibility, mechanical and antimicrobial properties of 3D printed composite scaffolds based on PVA/ Gold nanoparticles (AuNP)/ Ampicillin (AMP) for bone tissue engineering

Topsakal, A; Midha, S; Yuca, E; Tukay, A; Sasmazel, HT; Kalaskar, DM; Gunduz, O; (2021) Study on the cytocompatibility, mechanical and antimicrobial properties of 3D printed composite scaffolds based on PVA/ Gold nanoparticles (AuNP)/ Ampicillin (AMP) for bone tissue engineering. Materials Today Communications , 28 , Article 102458. 10.1016/j.mtcomm.2021.102458. Green open access

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Abstract

Over the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles.

Type: Article
Title: Study on the cytocompatibility, mechanical and antimicrobial properties of 3D printed composite scaffolds based on PVA/ Gold nanoparticles (AuNP)/ Ampicillin (AMP) for bone tissue engineering
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mtcomm.2021.102458
Publisher version: https://doi.org/10.1016/j.mtcomm.2021.102458
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Gold nanoparticle, PVA, Ampicillin, 3D printing, Bone tissue engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10128232
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