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Biomaterials for corneal endothelial cell culture and tissue engineering

Parekh, M; Romano, V; Hassanin, K; Testa, V; Wongvisavavit, R; Ferrari, S; Haneef, A; ... Levis, HJ; + view all (2021) Biomaterials for corneal endothelial cell culture and tissue engineering. Journal of Tissue Engineering , 12 pp. 1-9. 10.1177/2041731421990536. Green open access

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Abstract

The corneal endothelium is the posterior monolayer of cells that are responsible for maintaining overall transparency of the avascular corneal tissue via pump function. These cells are non-regenerative in vivo and therefore, approximately 40% of corneal transplants undertaken worldwide are a result of damage or dysfunction of endothelial cells. The number of available corneal donor tissues is limited worldwide, hence, cultivation of human corneal endothelial cells (hCECs) in vitro has been attempted in order to produce tissue engineered corneal endothelial grafts. Researchers have attempted to recreate the current gold standard treatment of replacing the endothelial layer with accompanying Descemet’s membrane or a small portion of stroma as support with tissue engineering strategies using various substrates of both biologically derived and synthetic origin. Here we review the potential biomaterials that are currently in development to support the transplantation of a cultured monolayer of hCECs.

Type: Article
Title: Biomaterials for corneal endothelial cell culture and tissue engineering
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2041731421990536
Publisher version: https://doi.org/10.1177%2F2041731421990536
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Cell & Tissue Engineering, Cell Biology, Cornea, tissue engineering, biomaterials, cell culture, endothelial cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10128224
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