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An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

Park, B-Y; Bethlehem, RA; Paquola, C; Larivière, S; Rodríguez-Cruces, R; Vos de Wael, R; Neuroscience in Psychiatry Network (NSPN) Consortium; ... Bernhardt, BC; + view all (2021) An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization. eLife , 10 , Article e64694. 10.7554/eLife.64694. Green open access

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Abstract

Adolescence is a critical time for the continued maturation of brain networks. Here, we assessed structural connectome development in a large longitudinal sample ranging from childhood to young adulthood. By projecting high-dimensional connectomes into compact manifold spaces, we identified a marked expansion of structural connectomes, with strongest effects in transmodal regions during adolescence. Findings reflected increased within-module connectivity together with increased segregation, indicating increasing differentiation of higher-order association networks from the rest of the brain. Projection of subcortico-cortical connectivity patterns into these manifolds showed parallel alterations in pathways centered on the caudate and thalamus. Connectome findings were contextualized via spatial transcriptome association analysis, highlighting genes enriched in cortex, thalamus, and striatum. Statistical learning of cortical and subcortical manifold features at baseline and their maturational change predicted measures of intelligence at follow-up. Our findings demonstrate that connectome manifold learning can bridge the conceptual and empirical gaps between macroscale network reconfigurations, microscale processes, and cognitive outcomes in adolescent development.

Type: Article
Title: An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.64694
Publisher version: http://dx.doi.org/10.7554/eLife.64694
Additional information: © 2021, Park et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: adolescence, connectome, human, longitudinal, multi-scale, neurodevelopment, neuroimaging, neuroscience
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10127659
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