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Advances in powder bed fusion 3D printing in drug delivery and healthcare.

Awad, A; Fina, F; Goyanes, A; Gaisford, S; Basit, AW; (2021) Advances in powder bed fusion 3D printing in drug delivery and healthcare. Advanced Drug Delivery Reviews 10.1016/j.addr.2021.04.025. (In press).

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Abstract

Powder bed fusion (PBF) is a 3D printing method that selectively consolidates powders into 3D objects using a power source. PBF has various derivatives; selective laser sintering/melting, direct metal laser sintering, electron beam melting and multi-jet fusion. These technologies provide a multitude of benefits that make them well suited for the fabrication of bespoke drug-laden formulations, devices and implants. This includes their superior printing resolution and speed, and ability to produce objects without the need for secondary supports, enabling them to precisely create complex products. Herein, this review article outlines the unique applications of PBF 3D printing, including the main principles underpinning its technologies and highlighting their novel pharmaceutical and biomedical applications. The challenges and shortcomings are also considered, emphasising on their effects on the 3D printed products, whilst providing a forward-thinking view.

Type: Article
Title: Advances in powder bed fusion 3D printing in drug delivery and healthcare.
Location: Netherlands
DOI: 10.1016/j.addr.2021.04.025
Publisher version: https://doi.org/10.1016/j.addr.2021.04.025
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 3D printed drug products and oral dosage forms, Additive manufacturing, DMLS, EBM, MJF, SLM, SLS, digital pharmaceutical sciences, drug delivery systems and prosthetics, personalized pharmaceuticals and medicines, printlets
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10127468
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