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Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors?

Pineda-Torra, I; Siddique, S; Waddington, KE; Farrell, R; Jury, EC; (2021) Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors? Frontiers in Endocrinology , 12 , Article 639757. 10.3389/fendo.2021.639757. Green open access

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Abstract

Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination and subsequent degeneration. Systemic lipid metabolism is disturbed in people with MS, and lipid metabolic pathways are crucial to the protective process of remyelination. The lipid-activated transcription factors liver X receptors (LXRs) are important integrators of lipid metabolism and immunity. Consequently, there is a strong interest in targeting these receptors in a number of metabolic and inflammatory diseases, including MS. We have reviewed the evidence for involvement of LXR-driven lipid metabolism in the dysfunction of peripheral and brain-resident immune cells in MS, focusing on human studies, both the relapsing remitting and progressive phases of the disease are discussed. Finally, we discuss the therapeutic potential of modulating the activity of these receptors with existing pharmacological agents and highlight important areas of future research.

Type: Article
Title: Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors?
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fendo.2021.639757
Publisher version: https://doi.org/10.3389/fendo.2021.639757
Language: English
Additional information: © 2021 Pineda-Torra, Siddique, Waddington, Farrell and Jury. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: cholesterol, lipid metabolism, liver X receptor, multiple sclerosis, nuclear receptor
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10127082
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