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Organization of feedback projections to mouse primary visual cortex

Morimoto, MM; Uchishiba, E; Saleem, AB; (2021) Organization of feedback projections to mouse primary visual cortex. iScience (102450) 10.1016/j.isci.2021.102450. Green open access

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Abstract

Top-down, context-dependent modulation of visual processing has been a topic of wide interest including in mouse primary visual cortex (V1). However, the organization of feedback projections to V1 is relatively unknown. Here, we investigated inputs to V1 by injecting retrograde tracers. We developed a software pipeline that maps labelled cell bodies to corresponding brain areas in the Allen Reference Atlas. We identified over 24 brain areas that provide inputs to V1 and quantified the relative strength of their projections. We also assessed the organisation of the projections, based on either the organisation of cell bodies in the source area (topography), or the distribution of projections across V1 (bias). Projections from most higher visual and some non-visual areas to V1 showed both topography and bias. Such organization of feedback projections to V1 suggests that parts of the visual field are differentially modulated, which may have ethological relevance for a navigating animal.

Type: Article
Title: Organization of feedback projections to mouse primary visual cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.isci.2021.102450
Publisher version: http://dx.doi.org/10.1016/j.isci.2021.102450
Language: English
Additional information: This article is published under a Creative Commons license Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10126949
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