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A mechanical model of early somite segmentation

Adhyapok, P; Piatkowska, AM; Norman, MJ; Clendenon, SG; Stern, CD; Glazier, JA; Belmonte, JM; (2021) A mechanical model of early somite segmentation. iScience , 24 (4) , Article 102317. 10.1016/j.isci.2021.102317. Green open access

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Abstract

Somitogenesis is often described using the clock-and-wavefront (CW) model, which does not explain how molecular signaling rearranges the pre-somitic mesoderm (PSM) cells into somites. Our scanning electron microscopy analysis of chicken embryos reveals a caudally-progressing epithelialization front in the dorsal PSM that precedes somite formation. Signs of apical constriction and tissue segmentation appear in this layer 3-4 somite lengths caudal to the last-formed somite. We propose a mechanical instability model in which a steady increase of apical contractility leads to periodic failure of adhesion junctions within the dorsal PSM and positions the future inter-somite boundaries. This model produces spatially periodic segments whose size depends on the speed of the activation front of contraction (F), and the buildup rate of contractility (Λ). The Λ/F ratio determines whether this mechanism produces spatially and temporally regular or irregular segments, and whether segment size increases with the front speed.

Type: Article
Title: A mechanical model of early somite segmentation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.isci.2021.102317
Publisher version: http://dx.doi.org/10.1016/j.isci.2021.102317
Language: English
Additional information: © 2021 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Poultry Embryology, Mechanical Modeling, Developmental Biology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10126948
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