Lechner, M;
Liu, J;
Lund, VJ;
(2020)
Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside.
Current Oncology Reports
, 22
(10)
10.1007/s11912-020-00947-2.
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Abstract
Purpose of Review: Sinonasal cancers are a heterogenous group of rare cancers for which histopathological diagnosis can be very challenging and treatment options are limited for advanced disease in particular. Here, we review the candidacy of novel diagnostic and prognostic biomarkers, and therapeutic targets for sinonasal cancers. / Recent Findings: Molecular multidimensional analyses of sinonasal cancers have been lagging behind other major cancers, but there are numerous publications describing the discovery of novel candidate biomarkers, e.g. the methylation classifier, originally developed for brain cancers, and gene expression panels for the prediction of response to induction chemotherapy in sinonasal undifferentiated carcinoma. The most promising biomarkers are summarized and discussed further with regard to their clinical applicability and future potential. /Summary: Many of the described novel biomarkers for sinonasal cancers will eventually overcome the pitfalls associated with the frequently non-specific immunohistological tests. With comprehensive, multidimensional molecular testing of these tumours in collaborative consortia projects, our better understanding of the molecular mechanisms of sinonasal cancers and their carcinogenesis will determine the most useful diagnostic and prognostic biomarkers, allow stringent multi-institutional validation and guide trials on targeted therapies.
| Type: | Article |
|---|---|
| Title: | Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11912-020-00947-2 |
| Publisher version: | https://doi.org/10.1007/s11912-020-00947-2 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. |
| Keywords: | Biomarkers; Therapeutic targets; Targeted therapies; Sinonasal cancer; Olfactory neuroblastoma; Esthesioneuroblastoma; Sinonasal melanoma; Sinonasal undifferentiated carcinoma (SNUC); Sinonasal neuroendocrine carcinoma (SNEC); Sinonasal adenocarcinoma; Sinonasal squamous cell cancer; Metastasis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10126855 |
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