Lim, EA;
Gnanadurai, R;
Ruffle, JK;
Lee, H;
Miller, RF;
Hyare, H;
(2021)
Neuroimaging of CNS infection in haematological malignancy: important signs and common diagnostic pitfalls.
Clinical Radiology
, 76
(6)
470.e1-470.e12.
10.1016/j.crad.2021.01.009.
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Abstract
Patients with haematological malignancy are at increased risk of developing central nervous system (CNS) infections, which are associated with significant morbidity and mortality. Neuroimaging plays a pivotal role in the diagnostic pathway of these patients; however, layers of complexity are added to image interpretation by the heterogeneity in imaging manifestations of haematological malignancies in the CNS, overlapping imaging features of CNS infection, treatment-related parenchymal changes and the presence of intracranial comorbidity. In this article, we review important intracranial findings of CNS infection cases accrued in 1,855 studies over more than a decade at a specialist tertiary centre. We offer schema to identify common and important neuroimaging features, discuss key differential diagnoses and frequent diagnostic pitfalls.
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