Boonstra, MJ;
Hilderink, BN;
Locati, ET;
Asselbergs, FW;
Loh, P;
van Dam, PM;
(2021)
Novel CineECG enables anatomical 3D localization and classification of bundle branch blocks.
Europace
, 23
(Suppl 1)
i80-i87.
10.1093/europace/euaa396.
Preview |
Text
Asselbergs_CineECG method normals BBB version 14_Clean.pdf - Accepted Version Download (878kB) | Preview |
Abstract
AIMS: Ventricular conduction disorders can induce arrhythmias and impair cardiac function. Bundle branch blocks (BBBs) are diagnosed by 12-lead electrocardiogram (ECG), but discrimination between BBBs and normal tracings can be challenging. CineECG computes the temporo-spatial trajectory of activation waveforms in a 3D heart model from 12-lead ECGs. Recently, in Brugada patients, CineECG has localized the terminal components of ventricular depolarization to right ventricle outflow tract (RVOT), coincident with arrhythmogenic substrate localization detected by epicardial electro-anatomical maps. This abnormality was not found in normal or right BBB (RBBB) patients. This study aimed at exploring whether CineECG can improve the discrimination between left BBB (LBBB)/RBBB, and incomplete RBBB (iRBBB). METHODS AND RESULTS: We utilized 500 12-lead ECGs from the online Physionet-XL-PTB-Diagnostic ECG Database with a certified ECG diagnosis. The mean temporo-spatial isochrone trajectory was calculated and projected into the anatomical 3D heart model. We established five CineECG classes: 'Normal', 'iRBBB', 'RBBB', 'LBBB', and 'Undetermined', to which each tracing was allocated. We determined the accuracy of CineECG classification with the gold standard diagnosis. A total of 391 ECGs were analysed (9 ECGs were excluded for noise) and 240/266 were correctly classified as 'normal', 14/17 as 'iRBBB', 55/55 as 'RBBB', 51/51 as 'LBBB', and 31 as 'undetermined'. The terminal mean temporal spatial isochrone contained most information about the BBB localization. CONCLUSION: CineECG provided the anatomical localization of different BBBs and accurately differentiated between normal, LBBB and RBBB, and iRBBB. CineECG may aid clinical diagnostic work-up, potentially contributing to the difficult discrimination between normal, iRBBB, and Brugada patients.
Type: | Article |
---|---|
Title: | Novel CineECG enables anatomical 3D localization and classification of bundle branch blocks |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1093/europace/euaa396 |
Publisher version: | http://dx.doi.org/10.1093/europace/euaa396 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | CineECG, Cardiac modelling, Electrocardiogram, Mean temporal spatial isochrones, Vectorcardiography, Ventricular conduction disorders |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
URI: | https://discovery.ucl.ac.uk/id/eprint/10126498 |
Archive Staff Only
![]() |
View Item |