QSM Challenge 2.0 Organization Committee;
Bilgic, B;
Langkammer, C;
Marques, JP;
Meineke, J;
Milovic, C;
Schweser, F;
(2021)
QSM reconstruction challenge 2.0: Design and report of results.
Magnetic Resonance in Medicine
10.1002/mrm.28754.
(In press).
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Abstract
PURPOSE: The aim of the second quantitative susceptibility mapping (QSM) reconstruction challenge (Oct 2019, Seoul, Korea) was to test the accuracy of QSM dipole inversion algorithms in simulated brain data. METHODS: A two-stage design was chosen for this challenge. The participants were provided with datasets of multi-echo gradient echo images synthesized from two realistic in silico head phantoms using an MR simulator. At the first stage, participants optimized QSM reconstructions without ground truth data available to mimic the clinical setting. At the second stage, ground truth data were provided for parameter optimization. Submissions were evaluated using eight numerical metrics and visual ratings. RESULTS: A total of 98 reconstructions were submitted for stage 1 and 47 submissions for stage 2. Iterative methods had the best quantitative metric scores, followed by deep learning and direct inversion methods. Priors derived from magnitude data improved the metric scores. Algorithms based on iterative approaches and total variation (and its derivatives) produced the best overall results. The reported results and analysis pipelines have been made public to allow researchers to compare new methods to the current state of the art. CONCLUSION: The synthetic data provide a consistent framework to test the accuracy and robustness of QSM algorithms in the presence of noise, calcifications and minor voxel dephasing effects. Total Variation-based algorithms produced the best results among all metrics. Future QSM challenges should assess whether this good performance with synthetic datasets translates to more realistic scenarios, where background fields and dipole-incompatible phase contributions are included.
| Type: | Article |
|---|---|
| Title: | QSM reconstruction challenge 2.0: Design and report of results. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.28754 |
| Publisher version: | https://doi.org/10.1002/mrm.28754 |
| Language: | English |
| Additional information: | © 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Assessment, challenge, dipole inversion, quantitative susceptibility mapping, reconstruction algorithms |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10126377 |
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