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Recent Developments and Characterization Techniques in 3D printing of Corneal Stroma Tissue

Ulag, S; Uysal, E; Bedir, T; Sengor, M; Ekren, N; Ustundag, CB; Midha, S; ... Gunduz, O; + view all (2021) Recent Developments and Characterization Techniques in 3D printing of Corneal Stroma Tissue. Polymers for Advanced Technologies , 32 (8) pp. 3287-3296. 10.1002/pat.5340. Green open access

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Abstract

Corneal stroma has a significant function in normal visual function. The corneal stroma is vulnerable because of being the thickest part of the cornea, as it can be affected easily by infections or injuries. Any problems on corneal stroma can result in blindness. Donor shortage for corneal transplantation is one of the main issues in corneal transplantation. To address this issue, the corneal tissue engineering focuses on replacing injured tissues and repairing normal functions. Currently, there are no available, engineered corneal tissues for widely accepted routine clinical treatment, but new emerging 3D printing applications are being recognized as a promising option. Recent in vitro researches revealed that the biocompatibility and regeneration possessions of 3D-printed hydrogels outperformed conventional tissue engineering approaches. The goal of this review is to highlight the current developments in the characterization of 3D cell-free and bioprinted hydrogels.

Type: Article
Title: Recent Developments and Characterization Techniques in 3D printing of Corneal Stroma Tissue
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pat.5340
Publisher version: https://doi.org/10.1002/pat.5340
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 3D printing, artificial cornea, characterization, corneal stroma, hydrogels
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10126348
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