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Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective.

Helfer, BM; Ponomarev, V; Patrick, PS; Blower, PJ; Feitel, A; Fruhwirth, GO; Jackman, S; ... Shingleton, WD; + view all (2021) Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective. Cytotherapy 10.1016/j.jcyt.2021.02.005. (In press). Green open access

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Abstract

Cell-based therapies have been making great advances toward clinical reality. Despite the increase in trial activity, few therapies have successfully navigated late-phase clinical trials and received market authorization. One possible explanation for this is that additional tools and technologies to enable their development have only recently become available. To support the safety evaluation of cell therapies, the Health and Environmental Sciences Institute Cell Therapy—Tracking, Circulation and Safety Committee, a multisector collaborative committee, polled the attendees of the 2017 International Society for Cell & Gene Therapy conference in London, UK, to understand the gaps and needs that cell therapy developers have encountered regarding safety evaluations in vivo. The goal of the survey was to collect information to inform stakeholders of areas of interest that can help ensure the safe use of cellular therapeutics in the clinic. This review is a response to the cellular imaging interests of those respondents. The authors offer a brief overview of available technologies and then highlight the areas of interest from the survey by describing how imaging technologies can meet those needs. The areas of interest include imaging of cells over time, sensitivity of imaging modalities, ability to quantify cells, imaging cellular survival and differentiation and safety concerns around adding imaging agents to cellular therapy protocols. The Health and Environmental Sciences Institute Cell Therapy—Tracking, Circulation and Safety Committee believes that the ability to understand therapeutic cell fate is vital for determining and understanding cell therapy efficacy and safety and offers this review to aid in those needs. An aim of this article is to share the available imaging technologies with the cell therapy community to demonstrate how these technologies can accomplish unmet needs throughout the translational process and strengthen the understanding of cellular therapeutics.

Type: Article
Title: Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jcyt.2021.02.005
Publisher version: https://doi.org/10.1016/j.jcyt.2021.02.005
Language: English
Additional information: © 2021 Published by Elsevier Inc. on behalf of International Society for Cell & Gene Therapy. Available under CC BY-NC-ND license
Keywords: biodistribution; cell therapy; fatein vivo tracking; non-invasivesafety
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/10126318
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