Gomez, A;
Rus, G;
Saffari, N;
(2016)
Use of shear waves for diagnosis and ablation monitoring of prostate cancer: a feasibility study.
In:
Journal of Physics: Conference Series.
IOP Publishing Ltd
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Abstract
Prostate cancer remains as a major healthcare issue. Limitations in current diagnosis and treatment monitoring techniques imply that there is still a need for improvements. The efficacy of prostate cancer diagnosis is still low, generating under and over diagnoses. High intensity focused ultrasound ablation is an emerging treatment modality, which enables the noninvasive ablation of pathogenic tissue. Clinical trials are being carried out to evaluate its longterm efficacy as a focal treatment for prostate cancer. Successful treatment of prostate cancer using non-invasive modalities is critically dependent on accurate diagnostic means and is greatly benefited by a real-time monitoring system. While magnetic resonance imaging remains the gold standard for prostate imaging, its wider implementation for prostate cancer diagnosis remains prohibitively expensive. Conventional ultrasound is currently limited to guiding biopsy. Elastography techniques are emerging as a promising real-time imaging method, as cancer nodules are usually stiffer than adjacent healthy prostatic tissue. In this paper, a new transurethral approach is proposed, using shear waves for diagnosis and ablation monitoring of prostate cancer. A finite-difference time domain model is developed for studying the feasibility of the method, and an inverse problem technique based on genetic algorithms is proposed for reconstructing the location, size and stiffness parameters of the tumour. Preliminary results indicate that the use of shear waves for diagnosis and monitoring ablation of prostate cancer is feasible.
| Type: | Proceedings paper |
|---|---|
| Title: | Use of shear waves for diagnosis and ablation monitoring of prostate cancer: a feasibility study |
| Event: | 14th Anglo-French Physical Acoustics Conference (AFPAC) |
| Location: | Frejus, FRANCE |
| Dates: | 14 January 2015 - 16 January 2015 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1742-6596/684/1/012006 |
| Publisher version: | https://doi.org/10.1088/1742-6596/684/1/012006 |
| Language: | English |
| Additional information: | Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10126215 |
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