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Zebrafish as a tractable model of human cardiovascular disease.

Bowley, G; Kugler, E; Wilkinson, R; Lawrie, A; van Eeden, F; Chico, TJA; Evans, PC; ... Serbanovic-Canic, J; + view all (2021) Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology 10.1111/bph.15473. (In press). Green open access

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Abstract

Mammalian models including non‐human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is an increasing desire for alternative model systems that provide excellent scientific value while replacing or reducing the use of mammals. Here we review the use of zebrafish, Danio rerio, to study cardiovascular development and disease. The anatomy and physiology of zebrafish and mammalian cardiovascular systems are compared, and we describe the use of zebrafish models in studying the mechanisms of cardiac (e.g. congenital heart defects, cardiomyopathy, conduction disorders, regeneration) and vascular (endothelial dysfunction and atherosclerosis, lipid metabolism, vascular ageing, neurovascular physiology and stroke) pathologies. We also review the use of zebrafish for studying pharmacological responses to cardiovascular drugs, and describe several features of zebrafish that make them a compelling model for in vivo screening of compounds for the treatment cardiovascular disease.

Type: Article
Title: Zebrafish as a tractable model of human cardiovascular disease.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bph.15473
Publisher version: https://doi.org/10.1111/bph.15473
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10126206
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