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Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach

Lauder, SN; Vanhaesebroeck, B; Gallimore, A; (2021) Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach. British Journal of Cancer 10.1038/s41416-021-01285-1. (In press). Green open access

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Abstract

Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.

Type: Article
Title: Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41416-021-01285-1
Publisher version: https://doi.org/10.1038/s41416-021-01285-1
Language: English
Additional information: © 2021 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Immunotherapy, Tumour immunology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10125946
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