Harley, J;
Clarke, BE;
Patani, R;
(2021)
The interplay of rna binding proteins, oxidative stress and mitochondrial dysfunction in als.
Antioxidants
, 10
(4)
, Article 552. 10.3390/antiox10040552.
Preview |
Text
antioxidants-10-00552.pdf - Published Version Download (803kB) | Preview |
Abstract
RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms of RNA binding protein dysregulation have been implicated in the pathomechanisms of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. In this review, we high-light the mechanistic interplay between RNA binding protein dysregulation, oxidative stress and mitochondrial dysfunction in ALS. We also discuss different potential therapeutic strategies targeting these pathways.
| Type: | Article |
|---|---|
| Title: | The interplay of rna binding proteins, oxidative stress and mitochondrial dysfunction in als |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/antiox10040552 |
| Publisher version: | http://dx.doi.org/10.3390/antiox10040552 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| Keywords: | RNA binding protein; oxidative stress; mitochondrial dysfunction; ALS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10125881 |
Archive Staff Only
 |
View Item |
