McBain, C;
Lawrie, TA;
Rogozińska, E;
Kernohan, A;
Robinson, T;
Jefferies, S;
(2021)
Treatment options for progression or recurrence of glioblastoma: a network meta-analysis.
Cochrane Database of Systematic Reviews
(12)
, Article CD013579. 10.1002/14651858.CD013579.pub2.
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Abstract
For treatment of first recurrence of GBM, among people previously treated with surgery and standard chemoradiotherapy, the combination treatments evaluated did not improve overall survival compared with LOM monotherapy and were often associated with a higher risk of severe adverse events. Limited evidence suggested that re‐operation with or without re‐irradiation and chemotherapy may be suitable for selected candidates. Evidence on second recurrence is sparse. Re‐irradiation with or without bevacizumab may be of value in selected individuals, but more evidence is needed.
| Type: | Article |
|---|---|
| Title: | Treatment options for progression or recurrence of glioblastoma: a network meta-analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/14651858.CD013579.pub2 |
| Publisher version: | https://doi.org/10.1002/14651858.CD013579.pub2 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10125871 |
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