McFadden, JJ;
Matthews, JC;
Scott, LA;
Parker, GJM;
Lohezic, M;
Parkes, LM;
(2021)
Optimization of quantitative susceptibility mapping for regional estimation of oxygen extraction fraction in the brain.
Magnetic Resonance in Medicine
10.1002/mrm.28789.
(In press).
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Abstract
Purpose: We sought to determine the degree to which oxygen extraction fraction (OEF) estimated using quantitative susceptibility mapping (QSM) depends on two critical acquisition parameters that have a significant impact on acquisition time: voxel size and final echo time. Methods: Four healthy volunteers were imaged using a range of isotropic voxel sizes and final echo times. The 0.7 mm data were downsampled at different stages of QSM processing by a factor of 2 (to 1.4 mm), 3 (2.1 mm), or 4 (2.8 mm) to determine the impact of voxel size on each analysis step. OEF was estimated from 11 veins of varying diameter. Inter- and intra- session repeatability were estimated for the opti-mal protocol by repeat scanning in 10 participants. Results: Final echo time was found to have no significant effect on OEF. The effect of voxel size was significant, with larger voxel sizes underestimating OEF, depending on the proximity of the vein to the superficial surface of the brain and on vein diameter. The last analysis step of estimating vein OEF values from susceptibility images had the largest dependency on voxel size. Inter- session coefficients of variation on OEF estimates of between 5.2% and 8.7% are reported, depending on the vein. Conclusion: QSM acquisition times can be minimized by reducing the final echo time but an isotropic voxel size no larger than 1 mm is needed to accurately estimate OEF in most medium/large veins in the brain. Such acquisitions can be achieved in under 4 min
| Type: | Article |
|---|---|
| Title: | Optimization of quantitative susceptibility mapping for regional estimation of oxygen extraction fraction in the brain |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.28789 |
| Publisher version: | http://dx.doi.org/10.1002/mrm.28789 |
| Language: | English |
| Additional information: | © 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | oxygen extraction fraction, quantitative susceptibility mapping, susceptibility weighted imaging, venous saturation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10125827 |
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