UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Is survival really better after repeated lung metastasectomy?

Fiorentino, F; Treasure, T; (2021) Is survival really better after repeated lung metastasectomy? Clinical & Experimental Metastasis , 38 (1) pp. 73-75. 10.1007/s10585-020-10061-z.

[img] Text
Fiorentino Treasure Letter to the Editori 200919.pdf - Accepted version
Access restricted to UCL open access staff until 30 October 2021.

Download (321kB)

Abstract

Several groups have observed that average survival time after a second lung metastasectomy is longer than after a first metastasectomy. The randomised controlled trial Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) found no survival benefit from lung metastasectomy. In fact, median survival was longer, and four-year overall survival was higher, in the control group than in those randomly assigned to metastasectomy, although not significantly so. The illusion of benefit is because survival without metastasectomy has been assumed to be near zero, as stated in Society of Thoracic Surgeons’ Expert Consensus Document on Pulmonary Metastasectomy 2019. It has been repeatedly found that survival is influenced by the selection of patients who have characteristics associated with better prognosis. The passage of time while monitoring and assessing patients, and observing their rate of progression, provides for immortal time bias. Reselection of the most favourable patients for repeated metastasectomy is the likely reason for any differences in survival between first and repeated metastasectomy operations.

Type: Article
Title: Is survival really better after repeated lung metastasectomy?
DOI: 10.1007/s10585-020-10061-z
Publisher version: http://doi.org/10.1007/s10585-020-10061-z
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Colorectal cancer, Lung metastasectomy, Survival analysis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics > Clinical Operational Research Unit
URI: https://discovery.ucl.ac.uk/id/eprint/10125603
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item