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Sample size calculations for randomized controlled trials and for prediction models

Fiorentino, F; Treasure, T; (2021) Sample size calculations for randomized controlled trials and for prediction models. Colorectal Disease , 23 (1) pp. 316-319. 10.1111/codi.15489.

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Abstract

The two study protocols are published in this issue Colorectal Disease: FALCON, a multicentre randomised controlled trial of strategies to reduce surgical site infection, and AFAR, a predictive model of atrial fibrillation after colonic resection. Both are exemplars of excellent research design that surgeon researchers should seek to emulate. Trial statisticians were involved at an early stage and the protocols have been through several rounds of peer review by trial methodologists, prior to being funded by the National Institute for Health Research (NIHR). In this article we address the important question of sample size calculations and how they should be approached for these very different forms of study.

Type: Article
Title: Sample size calculations for randomized controlled trials and for prediction models
DOI: 10.1111/codi.15489
Publisher version: http://doi.org/10.1111/codi.15489
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics > Clinical Operational Research Unit
URI: https://discovery.ucl.ac.uk/id/eprint/10125600
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