Pagliazzi, M;
Colom, L;
Vidal-Rosas, E;
Dragojević, T;
Parfentyeva, V;
Culver, JP;
Konugolu Venkata Sekar, S;
... Durduran, Turgut, T; + view all
(2021)
Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow.
Biomedical Optics Express
, 12
(3)
pp. 1499-1511.
10.1364/BOE.418882.
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Abstract
Time (or path length) resolved speckle contrast optical spectroscopy (TD-SCOS) at quasi-null (2.85 mm) source-detector separation was developed and demonstrated. The method was illustrated by in vivo studies on the forearm muscle of an adult subject. The results have shown that selecting longer photon path lengths results in higher hyperemic blood flow change and a faster return to baseline by a factor of two after arterial cuff occlusion when compared to SCOS without time resolution. This indicates higher sensitivity to the deeper muscle tissue. In the long run, this approach may allow the use of simpler and cheaper detector arrays compared to time resolved diffuse correlation spectroscopy that are based on readily available technologies. Hence, TD-SCOS may increase the performance and decrease cost of devices for continuous non-invasive, deep tissue blood flow monitoring.
| Type: | Article |
|---|---|
| Title: | Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/BOE.418882 |
| Publisher version: | https://doi.org/10.1364/BOE.418882 |
| Language: | English |
| Additional information: | © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10125507 |
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