UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The role of biomimetic hypoxia on cancer cell behaviour in 3d models: A systematic review

Liu, Y; Mohri, Z; Alsheikh, W; Cheema, U; (2021) The role of biomimetic hypoxia on cancer cell behaviour in 3d models: A systematic review. Cancers , 13 (6) , Article 1334. 10.3390/cancers13061334. Green open access

[thumbnail of cancers-13-01334-v2.pdf]
Preview
Text
cancers-13-01334-v2.pdf - Published Version

Download (2MB) | Preview

Abstract

The development of biomimetic, human tissue models is recognized as being an important step for transitioning in vitro research findings to the native in vivo response. Oftentimes, 2D models lack the necessary complexity to truly recapitulate cellular responses. The introduction of physiological features into 3D models informs us of how each component feature alters specific cellular response. We conducted a systematic review of research papers where the focus was the introduction of key biomimetic features into in vitro models of cancer, including 3D culture and hypoxia. We analysed outcomes from these and compiled our findings into distinct groupings to ascertain which biomimetic parameters correlated with specific responses. We found a number of biomimetic features which primed cancer cells to respond in a manner which matched in vivo response.

Type: Article
Title: The role of biomimetic hypoxia on cancer cell behaviour in 3d models: A systematic review
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cancers13061334
Publisher version: https://doi.org/10.3390/cancers13061334
Language: English
Additional information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: 3D; cancer models; hypoxia; cancer stem cells; drug resistance; epithelial-to-mesenchymal transition; invasion; migration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10125175
Downloads since deposit
56Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item