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Are we repeating mistakes of the past? A review of the evidence for esketamine

Horowitz, MA; Moncrieff, J; (2020) Are we repeating mistakes of the past? A review of the evidence for esketamine. The British Journal of Psychiatry pp. 1-4. 10.1192/bjp.2020.89. (In press). Green open access

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Abstract

Esketamine has been licensed for 'treatment-resistant depression' in the USA, UK and Europe. Licensing trials did not establish efficacy: two trials were negative, one showed a statistically significant but clinically uncertain effect, and a flawed discontinuation trial was included, against Food and Drug Administration precedent. Safety signals - deaths, including suicides, and bladder damage - were minimised.

Type: Article
Title: Are we repeating mistakes of the past? A review of the evidence for esketamine
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.2020.89
Publisher version: http://dx.doi.org/10.1192/bjp.2020.89
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Esketamine, antidepressants, depression, ketamine, suicide
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10125093
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