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Installing the "magic methyl" - C-H methylation in synthesis

Aynetdinova, D; Callens, MC; Hicks, HB; Poh, CYX; Shennan, BDA; Boyd, AM; Lim, ZH; ... Dixon, DJ; + view all (2021) Installing the "magic methyl" - C-H methylation in synthesis. Chemical Society reviews 10.1039/d0cs00973c. (In press). Green open access

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Abstract

The selective and efficient C-H methylation of sp2 and sp3 carbon centres has become a powerful transformation in the synthetic toolbox. Due to the potential for profound changes to physicochemical properties attributed to the installation of a "Magic Methyl" group at a strategic site in a lead compound, such techniques have become highly desirable in modern drug discovery and synthesis programmes. This review will cover the diverse techniques that have been employed to enable the selective installation of the C-Me bond in a wide range of chemical structures, from simple building blocks to complex drug-like architectures.

Type: Article
Title: Installing the "magic methyl" - C-H methylation in synthesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d0cs00973c
Publisher version: https://dx.doi.org/10.1039/d0cs00973c
Language: English
Additional information: Open Access Article. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10124998
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