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Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose

Elbadawi, M; Nikjoo, D; Gustafsson, T; Gaisford, S; Basit, AW; (2021) Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose. International Journal of Pharmaceutics , 595 , Article ARTN 120. 10.1016/j.ijpharm.2021.120197.

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Abstract

Oral films (OFs) continue to attract attention as drug delivery systems, particularly for pedatric and geriatric needs. However, immiscibility between different polymers limits the full potential of OFs from being explored. One example is pullulan (PUL), a novel biopolymer which often has to be blended with other polymers to reduce cost and alter its mechanical properties. In this study, the state-of-the-art in fabrication techniques, three-dimensional (3D) printing was used to produce hybrid film structures of PUL and hydroxypropyl methylcellulose (HPMC), which were loaded with caffeine as a model drug. 3D printing was used to control the spatial deposition of films. HPMC was found to increase the mean mechanical properties of PUL films, where the tensile strength, elastic modulus and elongation break increased from 8.9 to 14.5 MPa, 1.17 to 1.56 GPa and from 1.48% to 1.77%, respectively. In addition, the spatial orientation of the hybrid films was also explored to determine which orientation could maximize the mechanical properties of the hybrid films. The results revealed that 3D printing could modify the mechanical properties of PUL whilst circumventing the issues associated with immiscibility.

Type: Article
Title: Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose
DOI: 10.1016/j.ijpharm.2021.120197
Publisher version: http://dx.doi.org/10.1016/j.ijpharm.2021.120197
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 3D printing; 3D printed drug products; Printing medicines and pharmaceuticals; Pressure assisted microsyringe; Oral drug delivery films; Rheology
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10124966
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