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Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions

Cabral de Guimaraes, TA; Daich Varela, M; Georgiou, M; Michaelides, M; (2021) Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions. ritish Journal of Ophthalmology 10.1136/bjophthalmol-2020-318452. (In press). Green open access

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Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. The identification of the central role of vascular endothelial growth factor (VEGF) in the pathogenesis of neovascular AMD and the introduction of anti-VEGF agents as gold-standard treatment, have drastically changed its prognosis-something yet to be seen in dry AMD. Several therapeutic avenues with a wide variability of targets are currently being investigated in dry AMD. The approaches being investigated to reduce the rate of disease progression include, (1) drugs with antioxidative properties, (2) inhibitors of the complement cascade, (3) neuroprotective agents, (4) visual cycle inhibitors, (5) gene therapy and (6) cell-based therapies. A number of early phase clinical trials have provided promising results, with many more ongoing and anticipated in the near future. In this review, we aim to provide an update of the interventional trials to date and future prospects for the treatment of dry AMD.

Type: Article
Title: Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bjophthalmol-2020-318452
Publisher version: http://dx.doi.org/10.1136/bjophthalmol-2020-318452
Language: English
Additional information: © Author(s) (or their employer[s]) 2021. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: angiogenesis, degeneration, genetics, macula, retina
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10124670
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