Gabrio, A;
Hunter, R;
Mason, AJ;
Baio, G;
(2021)
Joint Longitudinal Models for Dealing With Missing at Random Data in Trial-Based Economic Evaluations.
Value in Health
, 24
(5)
pp. 699-706.
10.1016/j.jval.2020.11.018.
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Abstract
OBJECTIVES: In trial-based economic evaluation, some individuals are typically associated with missing data at some time point, so that their corresponding aggregated outcomes (eg, quality-adjusted life-years) cannot be evaluated. Restricting the analysis to the complete cases is inefficient and can result in biased estimates, while imputation methods are often implemented under a missing at random (MAR) assumption. We propose the use of joint longitudinal models to extend standard approaches by taking into account the longitudinal structure to improve the estimation of the targeted quantities under MAR. METHODS: We compare the results from methods that handle missingness at an aggregated (case deletion, baseline imputation, and joint aggregated models) and disaggregated (joint longitudinal models) level under MAR. The methods are compared using a simulation study and applied to data from 2 real case studies. RESULTS: Simulations show that, according to which data affect the missingness process, aggregated methods may lead to biased results, while joint longitudinal models lead to valid inferences under MAR. The analysis of the 2 case studies support these results as both parameter estimates and cost-effectiveness results vary based on the amount of data incorporated into the model. CONCLUSIONS: Our analyses suggest that methods implemented at the aggregated level are potentially biased under MAR as they ignore the information from the partially observed follow-up data. This limitation can be overcome by extending the analysis to a longitudinal framework using joint models, which can incorporate all the available evidence.
| Type: | Article |
|---|---|
| Title: | Joint Longitudinal Models for Dealing With Missing at Random Data in Trial-Based Economic Evaluations |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jval.2020.11.018 |
| Publisher version: | https://doi.org/10.1016/j.jval.2020.11.018 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Bayesian statistics, cost-effectiveness analysis, longitudinal models, missing data, missing at random |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10124505 |
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