Szpara, R;
Goyder, A;
Porter, MJ;
Hailes, HC;
Sheppard, TD;
(2021)
Regioselective Dehydration of Sugar Thioacetals under Mild Conditions.
Organic Letters
10.1021/acs.orglett.1c00424.
(In press).
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Abstract
Sugars are abundant in waste biomass, making them sustainable chiral building blocks for organic synthesis. The demand for chiral saturated heterocyclic rings for pharmaceutical applications is increasing as they provide well-defined three-dimensional frameworks that show increased metabolic resistance. A range of sugar thioacetals can be dehydrated selectively at C-2 under mild basic conditions, and the resulting ketene thioacetals can be applied to the production of useful chiral building blocks via further selective dehydration reactions.
| Type: | Article |
|---|---|
| Title: | Regioselective Dehydration of Sugar Thioacetals under Mild Conditions |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.orglett.1c00424 |
| Publisher version: | https://dx.doi.org/10.1021/acs.orglett.1c00424 |
| Language: | English |
| Additional information: | This version is the version of record. The article has been published under the CC BY licence. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10124427 |
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