Perocheau, D;
Touramanidou, L;
Gurung, S;
Gissen, P;
Baruteau, J;
(2021)
Clinical applications for exosomes: are we there yet?
British Journal of Pharmacology
10.1111/bph.15432.
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Abstract
Exosomes are a subset of extracellular vesicles essential for cell‐cell communication in health and disease with the ability to transport nucleic acids, functional proteins and other metabolites. Their clinical use as diagnostic biomarkers and therapeutic carriers has become a major field of research over recent years, generating rapidly expanding scientific interest and financial investment. Their reduced immunogenicity compared to liposomes or viral vectors and their ability to cross major physiological barriers like the blood‐brain barrier make them an appealing and innovative option as biomarkers and therapeutic agents. Here, we review the latest clinical developments of exosome biotechnology for diagnostic and therapeutic purposes, including the most recent COVID‐19 related exosome‐based clinical trials. We present current exosome engineering strategies for optimal clinical safety and efficacy and assess the technology developed for GMP compliant scaling up and storage approaches along with their limitations in pharmaceutical industry.
| Type: | Article |
|---|---|
| Title: | Clinical applications for exosomes: are we there yet? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bph.15432 |
| Publisher version: | https://doi.org/10.1111/bph.15432 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10124283 |
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