Bertoli, C;
de Bruin, RAM;
(2021)
Control of S phase duration: a replication capacity model with E2F transcription at its heart.
Molecular & Cellular Oncology
, Article 1839294. 10.1080/23723556.2020.1839294.
(In press).
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Abstract
DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.
| Type: | Article |
|---|---|
| Title: | Control of S phase duration: a replication capacity model with E2F transcription at its heart |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/23723556.2020.1839294 |
| Publisher version: | http://dx.doi.org/10.1080/23723556.2020.1839294 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way |
| Keywords: | DNA replication, S phase, DNA replication capacity, E2F-dependent transcription, genome stability |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10124165 |
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