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Control of S phase duration: a replication capacity model with E2F transcription at its heart

Bertoli, C; de Bruin, RAM; (2021) Control of S phase duration: a replication capacity model with E2F transcription at its heart. Molecular & Cellular Oncology , Article 1839294. 10.1080/23723556.2020.1839294. (In press). Green open access

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Abstract

DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.

Type: Article
Title: Control of S phase duration: a replication capacity model with E2F transcription at its heart
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/23723556.2020.1839294
Publisher version: http://dx.doi.org/10.1080/23723556.2020.1839294
Language: English
Additional information: © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way
Keywords: DNA replication, S phase, DNA replication capacity, E2F-dependent transcription, genome stability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10124165
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