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A gradient of Wnt activity positions the neurosensory domains of the inner ear

Żak, M; Daudet, N; (2021) A gradient of Wnt activity positions the neurosensory domains of the inner ear. eLife , 10 , Article e59540. 10.7554/elife.59540. (In press). Green open access

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Abstract

The auditory and vestibular organs of the inner ear and the neurons that innervate them originate from Sox2-positive and Notch-active neurosensory domains specified at early stages of otic development. Sox2 is initially present throughout the otic placode and otocyst, then it becomes progressively restricted to a ventro-medial domain. Using gain and loss-of-function approaches in the chicken otocyst, we show that these early changes in Sox2 expression are regulated in a dose-dependent manner by Wnt/beta-catenin signalling. Both high and very low levels of Wnt activity repress Sox2 and neurosensory competence. However, intermediate levels allow the maintenance of Sox2 expression and sensory organ formation. We propose that a dorso-ventral (high-to-low) gradient and wave of Wnt activity initiated at the dorsal rim of the otic placode progressively restricts Sox2 and Notch activity to the ventral half of the otocyst, thereby positioning the neurosensory competent domains in the inner ear.

Type: Article
Title: A gradient of Wnt activity positions the neurosensory domains of the inner ear
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/elife.59540
Publisher version: https://doi.org/10.7554/eLife.59540
Language: English
Additional information: © 2021, Żak & Daudet This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10124142
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