Brown, APY;
Cossell, L;
Strom, M;
Tyson, AL;
Vélez-Fort, M;
Margrie, TW;
(2021)
Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1.
Scientific Reports
, 11
, Article 4983. 10.1038/s41598-021-82353-7.
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Abstract
Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-range presynaptic connectivity onto excitatory and inhibitory neurons, mainly located in layer 2/3 (L2/3), of mouse primary visual cortex (V1). We find that the origins of long-range connections onto these two general cell classes-as well as their proportions-are quite similar, in contrast to the inputs on to a cell type in L6. These anatomical data suggest that distal inputs received by the general excitatory and inhibitory classes of neuron in L2/3 overlap considerably.
| Type: | Article |
|---|---|
| Title: | Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1 |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-021-82353-7 |
| Publisher version: | https://doi.org10.1038/s41598-021-82353-7 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10123655 |
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