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Impact of cancer evolution on immune surveillance and checkpoint inhibitor response

Wu, Y; Biswas, D; Swanton, C; (2021) Impact of cancer evolution on immune surveillance and checkpoint inhibitor response. Seminars in Cancer Biology 10.1016/j.semcancer.2021.02.013. (In press). Green open access

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Abstract

Intratumour heterogeneity (ITH) is pervasive across all cancers studied and may provide the evolving tumour multiple routes to escape immune surveillance. Immune checkpoint inhibitors (CPIs) are rapidly becoming standard of care for many cancers. Here, we discuss recent work investigating the influence of ITH on patient response to immune checkpoint inhibitor (CPI) therapy. At its simplest, ITH may confound the diagnostic accuracy of predictive biomarkers used to stratify patients for CPI therapy. Furthermore, ITH is fuelled by mechanisms of genetic instability that can both engage immune surveillance and drive immune evasion. A greater appreciation of the interplay between ITH and the immune system may hold the key to increasing the proportion of patients experiencing durable responses from CPI therapy.

Type: Article
Title: Impact of cancer evolution on immune surveillance and checkpoint inhibitor response
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.semcancer.2021.02.013
Publisher version: http://dx.doi.org/10.1016/j.semcancer.2021.02.013
Language: English
Additional information: © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Genomic instability, Immune checkpoint inhibitors, Immune surveillance, Intratumour heterogeneity, Neoantigens
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10123500
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