UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal

Berezhnov, AV; Fedotova, EI; Sergeev, AI; Teplov, IY; Abramov, AY; (2021) Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal. Cell Calcium , 94 , Article 102359. 10.1016/j.ceca.2021.102359. Green open access

[thumbnail of Cell Calcium Acceped.pdf]
Preview
Text
Cell Calcium Acceped.pdf - Accepted Version

Download (2MB) | Preview

Abstract

Dopamine is a neuromodulator and neurotransmitter responsible for a number of physiological processes. Dysfunctions of the dopamine metabolism and signalling are associated with neurological and psychiatric diseases. Here we report that in primary co-culture of neurons and astrocytes dopamine-induces calcium signal in astrocytes and suppress spontaneous synchronous calcium oscillations (SSCO) in neurons. Effect of dopamine on SSCO in neurons was dependent on calcium signal in astrocytes and could be modified by inhibition of dopamine-induced calcium signal or by stimulation of astrocytic calcium rise with ATP. Ability of dopamine to suppress SSCO in neurons was independent on D1- or D2- like receptors but dependent on GABA and alpha-adrenoreceptors. Inhibitor of monoaminoxidase bifemelane blocked effect of dopamine on astrocytes but also inhibited the effect dopamine on SSCO in neurons. These findings suggest that dopamine-induced calcium signal may stimulate release of neuromodulators such as GABA and adrenaline and thus suppress spontaneous calcium oscillations in neurons.

Type: Article
Title: Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceca.2021.102359
Publisher version: https://doi.org/10.1016/j.ceca.2021.102359
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Astrocyte, Calcium, Dopamine, Neuron
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10123264
Downloads since deposit
49Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item