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Modelling the dynamics of vesicle reshaping and scission under osmotic shocks

Vanhille-Campos, C; Šarić, A; (2021) Modelling the dynamics of vesicle reshaping and scission under osmotic shocks. Soft Matter 10.1039/D0SM02012E. (In press). Green open access

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Abstract

We study the effects of osmotic shocks on lipid vesicles via coarse-grained molecular dynamics simulations by explicitly considering the solute in the system. We find that depending on their nature (hypo- or hypertonic) such shocks can lead to bursting events or engulfing of external material into inner compartments, among other morphology transformations. We characterize the dynamics of these processes and observe a separation of time scales between the osmotic shock absorption and the shape relaxation. Our work consequently provides an insight into the dynamics of compartmentalization in vesicular systems as a result of osmotic shocks, which can be of interest in the context of early proto-cell development and proto-cell compartmentalisation.

Type: Article
Title: Modelling the dynamics of vesicle reshaping and scission under osmotic shocks
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/D0SM02012E
Publisher version: https://dx.doi/10.1039/D0SM02012E
Language: English
Additional information: This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/10123180
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