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Common fronto-temporal effective connectivity in humans and monkeys

Rocchi, F; Oya, H; Balezeau, F; Billig, AJ; Kocsis, Z; Jenison, RL; Nourski, KV; ... Petkov, CI; + view all (2021) Common fronto-temporal effective connectivity in humans and monkeys. Neuron , 109 (5) 852-868.e8. 10.1016/j.neuron.2020.12.026. Green open access

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Abstract

Human brain pathways supporting language and declarative memory are thought to have differentiated substantially during evolution. However, cross-species comparisons are missing on site-specific effective connectivity between regions important for cognition. We harnessed functional imaging to visualize the effects of direct electrical brain stimulation in macaque monkeys and human neurosurgery patients. We discovered comparable effective connectivity between caudal auditory cortex and both ventro-lateral prefrontal cortex (VLPFC, including area 44) and parahippocampal cortex in both species. Human-specific differences were clearest in the form of stronger hemispheric lateralization effects. In humans, electrical tractography revealed remarkably rapid evoked potentials in VLPFC following auditory cortex stimulation and speech sounds drove VLPFC, consistent with prior evidence in monkeys of direct auditory cortex projections to homologous vocalization-responsive regions. The results identify a common effective connectivity signature in human and nonhuman primates, which from auditory cortex appears equally direct to VLPFC and indirect to the hippocampus. VIDEO ABSTRACT.

Type: Article
Title: Common fronto-temporal effective connectivity in humans and monkeys
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2020.12.026
Publisher version: https://doi.org/10.1016/j.neuron.2020.12.026
Language: English
Additional information: © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: cognition, declarative memory, evolution, frontal cortex, hippocampus, language, neural principles, neuroimaging, neurophysiology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10123166
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