Bertrand, HGMJ;
Middleton, JA;
Baker, SN;
Glover, I;
Flecknell, PA;
(2021)
Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta).
Laboratory Animals
10.1177/0023677221990706.
(In press).
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Abstract
This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.
| Type: | Article |
|---|---|
| Title: | Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta) |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/0023677221990706 |
| Publisher version: | https://doi.org/10.1177%2F0023677221990706 |
| Language: | English |
| Additional information: | © 2021 by Laboratory Animals Limited. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Alphaxalone, neurosurgery, primate, somatosensory evoked potential |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10123153 |
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