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Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)

Bertrand, HGMJ; Middleton, JA; Baker, SN; Glover, I; Flecknell, PA; (2021) Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta). Laboratory Animals 10.1177/0023677221990706. (In press). Green open access

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Abstract

This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.

Type: Article
Title: Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0023677221990706
Publisher version: https://doi.org/10.1177%2F0023677221990706
Language: English
Additional information: © 2021 by Laboratory Animals Limited. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/).
Keywords: Alphaxalone, neurosurgery, primate, somatosensory evoked potential
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10123153
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