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Electrospun fixed dose combination fibers for the treatment of cardiovascular disease

Zhao, L; Orlu, M; Williams, GR; (2021) Electrospun fixed dose combination fibers for the treatment of cardiovascular disease. International Journal of Pharmaceutics 10.1016/j.ijpharm.2021.120426.

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Abstract

Fixed dose combinations (FDCs) offer an accessible way to simplify complex therapeutic regimens by the simultaneous presentation of multiple drugs in a single entity to the patient. However, encapsulation of hydrophobic drugs into FDCs possess a number of technical challenges. Electrospun nanofibers offer a convenient way to incorporate multiple hydrophobic drugs into a single formulation in a single step, via the use of an appropriate organic solvent system during fabrication. In this study, we report a series of novel fiber formulations comprising ethyl cellulose loaded with two hydrophobic drugs, spironolactone and nifedipine, either individually or in combination. The drugs are found to be present in the fibers in the form of amorphous solid dispersions, and these are stable at room temperature for 4 months. The products showed extended release profiles over more than 30 h. This formulation strategy offers potential to manage chronic cardiovascular conditions and overcome patient related non-adherence by providing a simplified treatment model.

Type: Article
Title: Electrospun fixed dose combination fibers for the treatment of cardiovascular disease
DOI: 10.1016/j.ijpharm.2021.120426
Publisher version: https://doi.org/10.1016/j.ijpharm.2021.120426
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: fixed dose combination, electrospinning, nanofiber, spironolactone, nifedipine, amorphous solid dispersion
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10123140
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