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Study protocol: The Heart and Brain Study

Suri, S; Bulte, D; Chiesa, S; Ebmeier, K; Jezzard, P; Rieger, S; Pitt, J; ... Mackay, C; + view all (2021) Study protocol: The Heart and Brain Study. Frontiers in Physiology 10.3389/fphys.2021.643725. (In press).

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Suri et al 2021 - HeartBrain Protocol.PDF - Accepted version
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Abstract

Background: It is well-established that what’s good for the heart is good for the brain; vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing both cardiovascular disease and dementia. However, the mechanisms underlying the heart-brain association remain unclear. Recent evidence suggests that impairments in vascular phenotypes and cerebrovascular reactivity (CVR) may play an important role in cognitive decline. The Heart and Brain Study combines state-of-the-art vascular ultrasound, cerebrovascular magnetic resonance imaging (MRI) and cognitive testing in participants of the long-running Whitehall II Imaging cohort to examine these physiological processes together. This paper describes the study protocol, data pre-processing and overarching objectives. / Methods and Design: The 775 participants of the Whitehall II Imaging cohort, aged 65 years or older in 2019, have received cardiovascular and clinical assessments at 5-year-intervals since 1985, as well as a 3T brain MRI scan and neuropsychological tests between 2012-2016 (Whitehall II Wave MRI-1). Approximately 20% of this cohort are selected for the Heart and Brain Study, which involves a single testing session at the University of Oxford (Wave MRI-2). Between 2019-2023, participants will undergo ultrasound scans of the ascending aorta and common carotid arteries, measures of central and peripheral blood pressure, and 3T MRI scans to measure CVR in response to 5% carbon dioxide in air, vessel-selective cerebral blood flow, and cerebrovascular lesions. The structural and diffusion MRI scans and neuropsychological battery conducted at Wave MRI-1 will also be repeated. Using this extensive life-course data, the Heart and Brain Study will examine how 30-year trajectories of vascular risk throughout midlife (40-70 years) affect vascular phenotypes, cerebrovascular health, longitudinal brain atrophy and cognitive decline at older ages. / Discussion: The study will generate one of the most comprehensive datasets to examine the longitudinal determinants of the heart-brain association. We will evaluate novel physiological processes in order to describe the optimal window for managing vascular risk in order to delay cognitive decline. Ultimately, the Heart and Brain Study will inform strategies to identify at-risk individuals for targeted interventions to prevent or delay dementia.

Type: Article
Title: Study protocol: The Heart and Brain Study
DOI: 10.3389/fphys.2021.643725
Publisher version: https://doi.org/10.3389/fphys.2021.643725
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ageing, MRI, cerebrovascular reactivity, dementia prevention, Cognition, Longitudinal cohort, cardiovascular, ultrasound, heart-brain
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10123019
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