Tyson, AL;
Margrie, TW;
(2021)
Mesoscale microscopy for micromammals: image analysis tools for understanding the rodent brain.
Progress in Biophysics and Molecular Biology
10.1016/j.pbiomolbio.2021.06.013.
(In press).
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Abstract
Over the last ten years, developments in whole-brain microscopy now allow for high-resolution imaging of intact brains of small animals such as mice. These complex images contain a wealth of information, but many neuroscience laboratories do not have all of the computational knowledge and tools needed to process these data. We review recent open source tools for registration of images to atlases, and the segmentation, visualisation and analysis of brain regions and labelled structures such as neurons. Since the field lacks fully integrated analysis pipelines for all types of whole-brain microscopy analysis, we propose a pathway for tool developers to work together to meet this challenge.
| Type: | Article |
|---|---|
| Title: | Mesoscale microscopy for micromammals: image analysis tools for understanding the rodent brain |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.pbiomolbio.2021.06.013 |
| Publisher version: | https://doi.org/10.1016/j.pbiomolbio.2021.06.013 |
| Language: | English |
| Additional information: | © 2021 The Authors. Published by Elsevier Ltd. under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Neuroscience, whole Brain microscopy, Image registration, Segmentation, Visualisation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10122960 |
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