UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?

Femminella, GD; Livingston, NR; Raza, S; van der Doef, T; Frangou, E; Love, S; Busza, G; ... Edison, P; + view all (2021) Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects? Alzheimer's Research and Therapy , 13 (1) , Article 47. 10.1186/s13195-021-00784-w. Green open access

[thumbnail of s13195-021-00784-w.pdf]
Preview
Text
s13195-021-00784-w.pdf - Published Version

Download (643kB) | Preview

Abstract

BACKGROUND: Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we evaluated the influence of insulin resistance on brain glucose metabolism, grey matter volume and white matter lesions (WMLs) in non-diabetic AD subjects. METHODS: In total, 130 non-diabetic AD subjects underwent MRI and [18F]FDG PET scans with arterial cannula insertion for radioactivity measurement. T1 Volumetric and FLAIR sequences were acquired on a 3-T MRI scanner. These subjects also had measurement of glucose and insulin levels after a 4-h fast on the same day of the scan. Insulin resistance was calculated by the updated homeostatic model assessment (HOMA2). For [18F]FDG analysis, cerebral glucose metabolic rate (rCMRGlc) parametric images were generated using spectral analysis with arterial plasma input function. RESULTS: In this non-diabetic AD population, HOMA2 was negatively associated with hippocampal rCMRGlc, along with total grey matter volumes. No significant correlation was observed between HOMA2, hippocampal volume and WMLs. CONCLUSIONS: In non-diabetic AD, peripheral insulin resistance is independently associated with reduced hippocampal glucose metabolism and with lower grey matter volume, suggesting that peripheral insulin resistance might influence AD pathology by its action on cerebral glucose metabolism and on neurodegeneration.

Type: Article
Title: Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s13195-021-00784-w
Publisher version: https://doi.org/10.1186/s13195-021-00784-w
Language: English
Additional information: © 2021 BioMed Central Ltd. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Alzheimer’s disease, Insulin resistance, Magnetic resonance imaging, Positron emission tomography imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10122837
Downloads since deposit
19Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item