Pfeiffer, T;
Li, Y;
Attwell, D;
(2021)
Diverse mechanisms regulating brain energy supply at the capillary level.
Current Opinion in Neurobiology
, 69
pp. 41-50.
10.1016/j.conb.2020.12.010.
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Abstract
Neural information processing depends critically on the brain's energy supply, which is provided in the form of glucose and oxygen in the blood. Regulation of this supply occurs by smooth muscle and contractile pericytes adjusting the diameter of arterioles and capillaries, respectively. Controversies exist over the relative importance of capillary and arteriolar level control, whether enzymatically generated signals or K+ ions are the dominant controller of cerebral blood flow, and the involvement of capillary endothelial cells. Here, we try to synthesise the relevant recent data into a coherent view of how brain energy supply is controlled and suggest approaches to answering key questions.
| Type: | Article |
|---|---|
| Title: | Diverse mechanisms regulating brain energy supply at the capillary level |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.conb.2020.12.010 |
| Publisher version: | http://dx.doi.org/10.1016/j.conb.2020.12.010 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10122788 |
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